 | 题 目: Explore "Dark Matter" of the Human Brain - Functional Tensor Imaging and Beyond 演讲人: 丁肇华 教授， 美国范德堡大学 主持人: 蒋田仔 研究员，中国科学院自动化研究所 时 间: 地 点: 智能化大厦三层第一会议室 |
Abstract
Functional magnetic resonance imaging (fMRI) detects changes in blood oxygenation level dependent (BOLD)signals from T2*-sensitive acquisitions, and is most effective in detecting activity in brain cortex. White matter usually appears to be dark under fMRI and is essential a dark matter where BOLD signals are often ignored. Based on our discovery that resting state fMRI signals exhibit anisotropy in temporal correlations along white matter tracts, we have proposed the concept of functional tensors, which may be used to detect and visualize synchronized functional activity along white matter fibers. This offers the potential of gaining entirely new insights into structure-function relations in white matter and thus disentangling complex neural networks in the human brain. This talk will present the historical background of the concept of functional tensors, various supporting evidences, and in vivo validations with human and non-human primates. The talk will be concluded by open discussions on potential issues and controversies in detecting white matter BOLD signals.
Biography
丁肇华博士是具有20多年生物医学工程和成像专业经验的资深专家。拥有生物医学工程本科、硕士和博士学位以及计算机硕士学位。先后在美国俄亥俄州立大学、耶鲁大学和范德堡大学学习和工作。目前担任范德堡大学成像科学研究所，电气工程和计算机系，以及生物医学工程系研究副教授，博士后导师。是国际电气工程师学会资深会员，任十余家国际期刊、会议和美国国家卫生部基金评审委员。在国际期刊和会议发表论文200余篇，论文被引用6000余次。主要研究医学磁共振及其在人脑功能结构关系中的应用，在几个重要方向上属国际领先。2013年首创了功能张量成像概念，在国际学术界引起了广泛关注。2014年荣膺国际电气工程师学会颁发的最佳论文奖。